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Gene of the month: TFE 3

20 Aug 2020

Abstract excerpt

Transcription factor enhancer 3 (TFE3), on the short arm of chromosome Xp11.23 and its protein, belongs to the microphthalmia transcription family (MiTF) of transcription factors. It shares close homology with another member of the family, MiTF which is involved in melanocyte development. When a cell is stressed and/or starved, TFE3 protein translocates into the nucleus. TFE3 gene fusions with multiple different...

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PMID: 32820043
DOI: 10.1136/jclinpath-2020-206899

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