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Endoxifen levels and metabolic phenotype-associated factors in Mexican Mestizo patients under tamoxifen treatment.

Pharmacogenomics - 1 Aug 2020

Jorge-Aarón Rangel-Méndez, Rodrigo Rubi-Castellanos, Esther Moo-Puc Rosa

Abstract excerpt

Aim: To evaluate plasma endoxifen levels and metabolic phenotype-associated factors in Mexican Mestizo patients under tamoxifen treatment. Patients & methods: A total of 138 breast cancer patients under tamoxifen treatment were cross-sectionally evaluated and side effects (SE) were recorded. CYP2D6 genetic phenotypes (GP) and metabolic phenotypes (MP) were assessed (metabolic poor [mPM], intermediate [mIM],...

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Identifiers

PMID: 32808577
DOI: 10.2217/pgs-2020-0061

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