Correct Identification of Cell of Origin May Explain Many Aspects of Cancer: The Role of Neuroendocrine Cells as Exemplified from the Stomach.

doi:10.3390/ijms21165751

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Article

Correct Identification of Cell of Origin May Explain Many Aspects of Cancer: The Role of Neuroendocrine Cells as Exemplified from the Stomach.

International journal of molecular sciences - 11 Aug 2020

Waldum Helge, Mjønes Patricia G

Abstract excerpt

Cancers are believed to originate from stem cells. Previously, the hypothesis was that tumors developed due to dedifferentiation of mature cells. We studied the regulation of gastric acid secretion and showed that gastrin through the gastrin receptor stimulates enterochromaffin-like (ECL) cell histamine release and proliferation. In animal and human studies, we and others showed that long-term hypergastrinemia...

Topics

Animals
Carcinogenesis
Humans
Mutation
Neoplasms
Neuroendocrine Cells
Stomach

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PMID: 32796591
DOI: 10.3390/ijms21165751
PMCID: PMC7461029

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