Article
Hypovascular tumors developed into hepatocellular carcinoma at a high rate despite the elimination of hepatitis C virus by direct-acting antivirals.
PloS one - 1 Jan 2020
Tabu Kazuaki, Mawatari Seiichi, Oda Kohei, Kumagai Kotaro, Inada Yukiko, Uto Hirofumi, Saisyoji Akiko, Hiramine Yasunari, Hashiguchi Masafumi, Tamai Tsutomu, Hori Takeshi, Fujisaki Kunio, Imanaka Dai, Kure Takeshi, Taniyama Ohki, Toyodome Ai, Ijuin Sho, Sakae Haruka, Sakurai Kazuhiro, Moriuchi Akihiro, Kanmura Shuji, Ido Akio
Abstract excerpt
BACKGROUND AND AIMS: Direct-acting antivirals (DAAs) against hepatitis C virus (HCV) exert high anti-HCV activity and are expected to show anti-inflammatory effects associated with HCV elimination. Furthermore, hepatocellular carcinoma (HCC) is known to dedifferentiate from hypovascular tumors, such as dysplastic nodules or well-differentiated HCC, to hypervascular tumors. We therefore explored whether or not...
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