Article
The effects of β1 and β1+2 adrenergic receptor blockade on the exercise-induced mobilization and ex vivo expansion of virus-specific T cells: implications for cellular therapy and the anti-viral immune effects of exercise.
Cell stress & chaperones - 1 Nov 2020
Kunz Hawley E, Agha Nadia H, Hussain Maryam, LaVoy Emily C, Smith Kyle A, Mylabathula Preteesh, Diak Douglass, Baker Forrest L, O'Connor Daniel P, Bond Richard A, Katsanis Emmanuel, Bollard Catherine M, Simpson Richard J
Abstract excerpt
The adoptive transfer of donor-derived virus-specific T cells (VSTs) is an effective treatment for infections following allogeneic hematopoietic cell transplantation. Acute exercise mobilizes effector lymphocytes and VSTs to the circulation and augments the ex vivo manufacture of VSTs. This study determined if β2 adrenergic receptor (AR) signaling precipitated the VST response to acute exercise. Healthy...
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