Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prediction of the Impact of Deleterious Nonsynonymous Single Nucleotide Polymorphisms on the Human RRM2B Gene: A Molecular Modeling Study.

BioMed research international - 1 Jan 2020

Ait El Cadi Chaimaa, Krami Al Mehdi, Charoute Hicham, Elkarhat Zouhair, Sifeddine Najat, Lakhiari Hamid, Rouba Hassan, Barakat Abdelhamid, Nahili Halima

Abstract excerpt

RRM2B gene encodes ribonucleoside-diphosphate reductase subunit M2 B, the p53-inducible small subunit (p53R2) of ribonucleotide reductase (RNR), an enzyme catalyzing dNTP synthesis for mitochondrial DNA. Defects in this gene may cause severe mitochondrial disease affecting mainly the nervous system. This study is aimed at examining the effect of deleterious nonsynonymous SNP (nsSNP) on the structure of the RRM2B...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Models, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Polymorphism, Single Nucleotide

Share to Protein Domains

Share to Ribonucleotide Reductases

Source

Open in PubMed Open full text

Identifiers

PMID: 32775440
DOI: 10.1155/2020/7614634
PMCID: PMC7399733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prediction of the Impact of Deleterious Nonsynonymous Single Nucleotide Polymorphisms on the Human RRM2B Gene: A Molecular Modeling Study.PMID 32775440Read ↗

Prediction of Deleterious Single Nucleotide Polymorphisms in Human p53 GeneSemantic proximity Read ↗

Combining Ramachandran plot and molecular dynamics simulation for structural-based variant classification: Using TP53 variants as modelSemantic proximity Read ↗

Impact of N221S missense mutation in human ribonucleotide reductase small subunit b on mitochondrial DNA depletion syndrome.Semantic proximity Read ↗

In silico explanation for the causalities of deleterious RNF213 SNPs in Moyamoya disease and insulin resistance.Semantic proximity Read ↗

Comprehensive bioinformatics analysis of structural and functional consequences of deleterious missense mutations in the human QDPR gene.Semantic proximity Read ↗

In Silico Screening, Molecular Dynamics Simulation and Binding Free Energy Identify Single-Point Mutations That Destabilize p53 and Reduce Binding to DNA.Semantic proximity Read ↗

A comprehensive in silico investigation into the nsSNPs of Drd2 gene predicts significant functional consequences in dopamine signaling and pharmacotherapy.Semantic proximity Read ↗

In‑silico analysis predicting effects of some Protein conding SNPs of human tumor suppressor protein53 (TP53 gene) by using different Bioinformatic toolsSemantic proximity Read ↗

A comprehensive in silico investigation into the pathogenic SNPs in the RTEL1 gene and their biological consequences.Semantic proximity Read ↗

Exploring the structural and functional effect of pRB by significant nsSNP in the coding region of RB1 gene causing retinoblastoma.Semantic proximity Read ↗

Computational identification and analysis of deleterious non-synonymous single nucleotide polymorphisms (nsSNPs) in the human POR gene: a structural and functional impact.Semantic proximity Read ↗

A comprehensive <i>in silico</i> investigation into the nsSNPs of <i>Drd2</i> gene predicts significant functional consequences in dopamine signaling and pharmacotherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.