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Article

The phenomenal epigenome in neurodevelopmental disorders.

Human molecular genetics - 30 Sept 2020

Ciptasari Ummi, van Bokhoven Hans

Abstract excerpt

Disruption of chromatin structure due to epimutations is a leading genetic etiology of neurodevelopmental disorders, collectively known as chromatinopathies. We show that there is an increasing level of convergence from the high diversity of genes that are affected by mutations to the molecular networks and pathways involving the respective proteins, the disrupted cellular and subcellular processes, and their...

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Identifiers

PMID: 32766754
DOI: 10.1093/hmg/ddaa175
PMCID: PMC7530535

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