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The Impact of Coilin Nonsynonymous SNP Variants E121K and V145I on Cell Growth and Cajal Body Formation: The First Characterization.

Genes - 5 Aug 2020

Yao Yue, Tan Heng Wee, Liang Zhan-Ling, Wu Gao-Qi, Xu Yan-Ming, Lau Andy T Y

Abstract excerpt

Coilin is the main component of Cajal body (CB), a membraneless organelle that is involved in the biogenesis of ribonucleoproteins and telomerase, cell cycle, and cell growth. The disruption of CBs is linked to neurodegenerative diseases and potentially cancers. The coilin gene (COIL) contains two nonsynonymous SNPs: rs116022828 (E121K) and rs61731978 (V145I). Here, we investigated for the first time the...

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PMID: 32764415
DOI: 10.3390/genes11080895
PMCID: PMC7463897

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