Article
The emerging role of PARP inhibitors in prostate cancer.
Expert review of anticancer therapy - 1 Aug 2020
Stellato Marco, Guadalupi Valentina, Sepe Pierangela, Mennitto Alessia, Claps Mélanie, Zattarin Emma, Verzoni Elena, Valdagni Riccardo, De Braud Filippo Gm, Santini Daniele, Tonini Giuseppe, Procopio Giuseppe
Abstract excerpt
INTRODUCTION: In prostate cancer , there has recently been an emerging interest in mutations in genes belonging to the homologous recombination repair (HRR) pathway and in the inhibition of poly (ADP-ribose) polymerase (PARP) proteins. AREAS COVERED: Mutations in the HRR genes, including BRCA1, BRCA2, and Ataxia-Telangiesctasia mutated (ATM), have been reported in prostate cancer, with different incidence in the...
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