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Article

Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential

1 Jul 2020

Abstract excerpt

Ureteric bud (UB) is the embryonic kidney progenitor tissue that gives rise to the collecting duct and lower urinary tract. UB-like structures generated from human pluripotent stem cells by previously reported methods show limited developmental ability and limited branching. Here we report a method to generate UB organoids that possess epithelial polarity and tubular lumen and repeat branching morphogenesis. We...

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PMID: 32726627
DOI: 10.1016/j.celrep.2020.107963

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