Article
Selecting human papillomavirus genotypes to optimize the performance of screening tests among South African women.
Cancer medicine - 1 Sept 2020
Johnson Lauren G, Saidu Rakiya, Mbulawa Zizipho, Williamson Anna-Lise, Boa Rosalind, Tergas Ana, Moodley Jennifer, Persing David, Campbell Scott, Tsai Wei-Yann, Wright Thomas C, Denny Lynette, Kuhn Louise
Abstract excerpt
Human papillomavirus (HPV) testing is highly sensitive compared to cytology, with the trade-off of being less specific. We investigated whether select combinations of HPV genotypes, ascertained by Linear Array (LA) and Xpert HPV (GX), can optimize sensitivity/specificity trade-offs to detect high-grade cervical intraepithelial neoplasia (CIN2+). In a study in Cape Town, South Africa, 586 women living without and...
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