An overview of the multi-pronged approach in the diagnosis of Alport syndrome for 22 children in Northeast China.

Abstract excerpt

BACKGROUND: Alport syndrome (AS) is a kind of progressive hereditary nephritis induced by mutations of different genes that encode collagen IV. The affected individuals usually develop hematuria during childhood, accompanying with gradual deterioration of renal functions. In this study, the multi-pronged approach was employed to improve the diagnosis of AS. METHODS: Twenty-two children were diagnosed and treated...

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