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Article

Extracellular Matrix Rigidity Modulates Human Cervical Smooth Muscle Contractility-New Insights into Premature Cervical Failure and Spontaneous Preterm Birth.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Jan 2021

Vink Joy, Yu Victoria, Dahal Sudip, Lohner James, Stern-Asher Conrad, Mourad Mirella, Davis George, Xue Zenghui, Wang Shuang, Myers Kristin, Kitajewski Jan, Chen Xiaowei, Wapner Ronald J, Ananth Cande V, Sheetz Michael, Gallos George

Abstract excerpt

Spontaneous preterm birth (sPTB), a major cause of infant morbidity and mortality, must involve premature cervical softening/dilation for a preterm vaginal delivery to occur. Yet, the mechanism behind premature cervical softening/dilation in humans remains unclear. We previously reported the non-pregnant human cervix contains considerably more cervical smooth muscle cells (CSMC) than historically appreciated and...

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Source

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Identifiers

PMID: 32700284
DOI: 10.1007/s43032-020-00268-6
PMCID: PMC9344974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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