Article
Increased blood COASY DNA methylation levels a potential biomarker for early pathology of Alzheimer's disease.
Scientific reports - 22 Jul 2020
Kobayashi Nobuyuki, Shinagawa Shunichiro, Niimura Hidehito, Kida Hisashi, Nagata Tomoyuki, Tagai Kenji, Shimada Kazuya, Oka Naomi, Shikimoto Ryo, Noda Yoshihiro, Nakajima Shinichiro, Mimura Masaru, Shigeta Masahiro, Kondo Kazuhiro
Abstract excerpt
Early diagnosis of dementia including Alzheimer's disease (AD) is an urgent medical and welfare issue. However, to date, no simple biometrics have been available. We reported that blood DNA methylation levels of the COASY gene, which encodes coenzyme A synthase, were increased in individuals with AD and amnestic mild cognitive impairment (aMCI). The present study sought to replicate these findings with larger...
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