Article
The origins and genomic diversity of American Civil War Era smallpox vaccine strains.
Genome biology - 20 Jul 2020
Duggan Ana T, Klunk Jennifer, Porter Ashleigh F, Dhody Anna N, Hicks Robert, Smith Geoffrey L, Humphreys Margaret, McCollum Andrea M, Davidson Whitni B, Wilkins Kimberly, Li Yu, Burke Amanda, Polasky Hanna, Flanders Lowell, Poinar Debi, Raphenya Amogelang R, Lau Tammy T Y, Alcock Brian, McArthur Andrew G, Golding G Brian, Holmes Edward C, Poinar Hendrik N
Abstract excerpt
Vaccination has transformed public health, most notably including the eradication of smallpox. Despite its profound historical importance, little is known of the origins and diversity of the viruses used in smallpox vaccination. Prior to the twentieth century, the method, source and origin of smallpox vaccinations remained unstandardised and opaque. We reconstruct and analyse viral vaccine genomes associated with...
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