Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Kurarinone Inhibits HCoV-OC43 Infection by Impairing the Virus-Induced Autophagic Flux in MRC-5 Human Lung Cells

14 Jul 2020

Abstract excerpt

Kurarinone is a prenylated flavonone isolated from the roots of Sophora flavescens. Among its known functions, kurarinone has both anti-apoptotic and anti-inflammatory properties. Coronaviruses (CoVs), including HCoV-OC43, SARS-CoV, MERS-CoV, and SARS-CoV-2, are the causative agents of respiratory virus infections that range in severity from the common cold to severe pneumonia. There are currently no effective...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Bioactive natural compounds
Share to Calcium signaling and nucleotide metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32674356
DOI: 10.3390/jcm9072230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kurarinone Inhibits HCoV-OC43 Infection by Impairing the Virus-Induced Autophagic Flux in MRC-5 Human Lung CellsPMID 32674356Read ↗

Natural Bis-Benzylisoquinoline Alkaloids-Tetrandrine, Fangchinoline, and Cepharanthine, Inhibit Human Coronavirus OC43 Infection of MRC-5 Human Lung CellsSemantic proximity Read ↗

Fangchinoline Inhibits the Pedv Replication in Intestinal Epithelial Cells Via Autophagic Flux SuppressionSemantic proximity Read ↗

Fangchinoline inhibits the PEDV replication in intestinal epithelial cells via autophagic flux suppressionSemantic proximity Read ↗

Suppression of SARS‐CoV‐2 infection in ex‐vivo human lung tissues by targeting class III phosphoinositide 3‐kinaseSemantic proximity Read ↗

Targeting PI3K Signaling for Broad Inhibition of β-Coronavirus InfectionSemantic proximity Read ↗

Safe and Sensitive Antiviral Screening Platform Based on Recombinant Human Coronavirus OC43 Expressing the Luciferase Reporter GeneSemantic proximity Read ↗

Antiviral Effect of Hyunggaeyungyo-tang on A549 Cells Infected with Human CoronavirusSemantic proximity Read ↗

Tetrandrine-Driven Autophagy Suppresses SARS-CoV-2 Replication by Modulating Cholesterol and IGF Signaling PathwaysSemantic proximity Read ↗

Brilacidin, a COVID‐19 drug candidate, demonstrates broad‐spectrum antiviral activity against human coronaviruses OC43, 229E, and NL63 through targeting both the virus and the host cellSemantic proximity Read ↗

Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)Semantic proximity Read ↗

An anti-SARS-CoV-2 formula consisting volatile oil from TCM through inhibiting multiple targets in cultured cellsSemantic proximity Read ↗

Linoleic acid binds to SARS-CoV-2 RdRp and represses replication of seasonal human coronavirus OC43Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.