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Article

Calcineurin inhibitors in nephrotic syndrome secondary to podocyte gene mutations: a systematic review.

Pediatric nephrology (Berlin, Germany) - 1 Jun 2021

Malakasioti Georgia, Iancu Daniela, Tullus Kjell

Abstract excerpt

BACKGROUND: Calcineurin inhibitor (CNI) use in genetic steroid-resistant nephrotic syndrome (SRNS) is controversial as response rate is reported to be lower than non-genetic disease and no plausible mechanism of action is known. METHODS: We reviewed PubMed for publications on CNI use in hereditary SRNS to determine (1) CNI response rate; (2) impact of response on renal outcome; and (3) clinical and molecular...

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Identifiers

PMID: 32651716
DOI: 10.1007/s00467-020-04695-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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