Article
Identification of monogenic variants in steroid-resistant and steroid-sensitive nephrotic syndrome.
Pediatric nephrology (Berlin, Germany) - 1 Jun 2026
Mansour Bshara, Lemberg Katharina, Schneider Ronen, Saida Ken, Elmubarak Izzeldin, Yu Seyoung, Yousef Kirollos, Nicolas Frank Camille, Riedhammer Korbinian M, Zahoor Muhammad Yasir, Kolvenbach Caroline M, Merz Lea M, Mertens Nils D, Bao Aaron, Salmanullah Daanya, Kalkar Gina, Hölzel Selina, Zion Elena, Marchuk Daniel, Lomjansook Kraisoon, Braun Alina, Franken Gijs A C, Eid Loai A, Awad Hazem Subhi H, Al Saffar Muna, Soliman Neveen A, Nabhan Marwa M, Kari Jameela A, El Desoky Sherif, Shalaby Mohamed A, Ooda Said, Fathy Hanan M, Mane Shrikant, Shril Shirlee, Somers Michael J G, Buerger Florian, Hildebrandt Friedhelm
Abstract excerpt
BACKGROUND: Steroid-resistant nephrotic syndrome (SRNS) constitutes the second most common cause of chronic kidney disease (CKD) in children. A monogenic cause can be identified in approximately 25% of SRNS cases. In contrast, steroid-sensitive or steroid-dependent nephrotic syndrome (SSNS/SDNS) is typically attributed to multifactorial or immunological causes and rarely linked to monogenic etiology. METHODS: We...
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