Article
Transcriptional frameshifts contribute to protein allergenicity.
The Journal of clinical investigation - 1 Oct 2020
Thouvenot Benoit, Roitel Olivier, Tomasina Julie, Hilselberger Benoit, Richard Christelle, Jacquenet Sandrine, Codreanu-Morel Françoise, Morisset Martine, Kanny Gisèle, Beaudouin Etienne, Delebarre-Sauvage Christine, Olivry Thierry, Favrot Claude, Bihain Bernard E
Abstract excerpt
Transcription infidelity (TI) is a mechanism that increases RNA and protein diversity. We found that single-base omissions (i.e., gaps) occurred at significantly higher rates in the RNA of highly allergenic legumes. Transcripts from peanut, soybean, sesame, and mite allergens contained a higher density of gaps than those of nonallergens. Allergen transcripts translate into proteins with a cationic carboxy...
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