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Article

Medical Management of newly diagnosed breast cancer in a BRCA1/2 mutation carrier.

The breast journal - 1 Aug 2020

Desai Neelam V, Tung Nadine M

Abstract excerpt

Germline BRCA1/2 mutations may be infrequent in unselected breast cancer population but are concentrated in those with triple-negative breast cancer or high-risk family history. Insight into the biology of BRCA mutation is now allowing a targeted therapeutic approach to these carriers with breast cancer. Functional BRCA genes play a critical role in DNA damage repair. Agents such as platinum salts and poly...

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Identifiers

PMID: 32633033
DOI: 10.1111/tbj.13972

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