Article
A cell-level quality control workflow for high-throughput image analysis.
BMC bioinformatics - 2 Jul 2020
Qiu Minhua, Zhou Bin, Lo Frederick, Cook Steven, Chyba Jason, Quackenbush Doug, Matzen Jason, Li Zhizhong, Mak Puiying Annie, Chen Kaisheng, Zhou Yingyao
Abstract excerpt
BACKGROUND: Image-based high throughput (HT) screening provides a rich source of information on dynamic cellular response to external perturbations. The large quantity of data generated necessitates computer-aided quality control (QC) methodologies to flag imaging and staining artifacts. Existing image- or patch-level QC methods require separate thresholds to be simultaneously tuned for each image quality metric...
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