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Highly efficient vaccines for Bluetongue virus and a related Orbivirus based on reverse genetics

28 Jun 2020

Abstract excerpt

Bluetongue virus (BTV) reverse genetics (RG), available since 2007, has allowed the dissection of the virus replication cycle, including discovery of a primary replication stage. This information has allowed the generation of Entry-Competent-Replication-Abortive (ECRA) vaccines, which enter cells and complete primary replication but fail to complete the later stage. A series of vaccine trials in sheep and cattle...

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PMID: 32610251
DOI: 10.1016/j.coviro.2020.05.003

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