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Article

COMT by DRD3 Epistatic Interaction in Modulating Behaviors in Children with ADHD: A Pharmaco-Dynamic Behavioral Approach.

Journal of attention disorders - 1 Oct 2021

Fageera Weam, Grizenko Natalie, Sengupta Sarojini M, Schmitz Norbert, Joober Ridha

Abstract excerpt

OBJECTIVE: Examining the joint effect of two functional variants in two dopamine-related genes (DRD3 and COMT) on ADHD-relevant behaviors under three experimental conditions (EC). METHOD: 362 children with ADHD were assessed by parents and teachers during a week of baseline evaluation, followed by 1 week of MPH and placebo, administered in a double-blind crossover design. RESULTS: Statistically significant 3-way...

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Source

Identifiers

PMID: 32564645
DOI: 10.1177/1087054720934191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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