Article
Genome-wide association study identifies CDH13 as a susceptibility gene for rhododendrol-induced leukoderma.
Pigment cell & melanoma research - 1 Nov 2020
Okamura Ken, Abe Yuko, Naka Izumi, Ohashi Jun, Yagami Akiko, Matsunaga Kayoko, Kobayashi Yui, Fukai Kazuyoshi, Tanemura Atsushi, Katayama Ichiro, Masui Yukiko, Ito Akiko, Yamashita Toshiharu, Nagai Hiroshi, Nishigori Chikako, Oiso Naoki, Aoyama Yumi, Araki Yuta, Saito Toru, Hayashi Masahiro, Hozumi Yutaka, Suzuki Tamio
Abstract excerpt
Racemic RS-4-(4-hydroxyphenyl)-2-butanol (rhododendrol; trade name: Rhododenol [RD]), which is used in topical skin-lightening cosmetics, was unexpectedly reported in Japan to induce leukoderma or vitiligo called RD-induced leukoderma (RIL) after repeated application. To our knowledge, no studies have investigated chemical-induced vitiligo pathogenesis on a genome-wide scale. Here, we conducted a genome-wide...
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