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Polymorphism analysis of the Gly972Arg IRS-1 and Gly1057Asp IRS-2 genes in obese pregnant women.

Reproductive biology - 1 Sept 2020

Górska Aleksandra, Wolek Marlena, Czerny Bogusław, Uzar Izabela, Seremak-Mrozikiewicz Agnieszka, Olbromski Piotr, Baraniak Justyna, Kania-Dobrowolska Małgorzata, Sienko Magdalena, Bogacz Anna

Abstract excerpt

Genes encoding insulin receptor substrates IRS-1 and IRS-2 perform key functions in the insulin pathway. Numerous authors have suggested that single-nucleotide polymorphism (SNP) changes in the DNA sequence may be associated with the development of obesity, insulin resistance and type 2 diabetes. The Gly972Arg polymorphism of the IRS-1 gene and the Gly1057Asp polymorphism of the IRS-2 gene are believed to be...

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Identifiers

PMID: 32540195
DOI: 10.1016/j.repbio.2020.05.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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