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Article

Central hypogonadism in Klinefelter syndrome: report of two cases and review of the literature.

Journal of endocrinological investigation - 1 Mar 2021

Cangiano Biagio, Indirli Rita, Profka Eriselda, Castellano Elena, Goggi Giovanni, Vezzoli Valeria, Mantovani Giovanna, Arosio Maura, Persani Luca, Borretta Giorgio, Ferrante Emanuele, Bonomi Marco

Abstract excerpt

PURPOSE: Klinefelter syndrome (KS) is characterized by late adolescence/young adulthood onset of primary hypogonadism. Hypogonadotropic hypogonadism (HH), when congenital, is usually associated with absent/incomplete puberty and low/normal gonadotropins. We report the clinical and genetic features of two subjects with KS and an unexpected HH hormone profile. METHODS: Magnetic resonance imaging (MRI) of...

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Identifiers

PMID: 32537678
DOI: 10.1007/s40618-020-01324-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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