Article
APOE polymorphism and diabetic nephropathy.
Clinical and experimental nephrology - 1 Apr 2014
Araki Shin-ichi
Abstract excerpt
Epidemiological studies suggest the existence of a genetic susceptibility to the development of diabetic nephropathy. The apolipoprotein E gene (APOE), which is well known to have a polymorphism (ε2, ε3, and ε4) in exon 4, has been considered a candidate gene susceptible to this complication, because this variation was reportedly involved in lipid metabolism. To date, numerous case-control studies in patients...
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