Article
Upregulation of mesothelial genes in ovarian carcinoma cells is associated with an unfavorable clinical outcome and the promotion of cancer cell adhesion.
Molecular oncology - 1 Sept 2020
Ojasalu Kaire, Brehm Corinna, Hartung Kristin, Nischak Maximilian, Finkernagel Florian, Rexin Peter, Nist Andrea, Pavlakis Evangelos, Stiewe Thorsten, Jansen Julia M, Wagner Uwe, Gattenlöhner Stefan, Bräuninger Andreas, Müller-Brüsselbach Sabine, Reinartz Silke, Müller Rolf
Abstract excerpt
A hallmark of ovarian high-grade serous carcinoma (HGSC) is its early and massive peritoneal dissemination via the peritoneal fluid. It is generally believed that tumor cells must breach the mesothelium of peritoneal organs to adhere to the underlying extracellular matrix (ECM) and initiate metastatic growth. However, the molecular mechanisms underlying these processes are only partially understood. Here, we have...
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