Mutations in SARS-CoV-2 viral RNA identified in Eastern India: Possible implications for the ongoing outbreak in India and impact on viral structure and host susceptibility.

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Mutations in SARS-CoV-2 viral RNA identified in Eastern India: Possible implications for the ongoing outbreak in India and impact on viral structure and host susceptibility.

Journal of biosciences - 1 Jan 2020

Maitra Arindam, Sarkar Mamta Chawla, Raheja Harsha, Biswas Nidhan K, Chakraborti Sohini, Singh Animesh Kumar, Ghosh Shekhar, Sarkar Sumanta, Patra Subrata, Mondal Rajiv Kumar, Ghosh Trinath, Chatterjee Ananya, Banu Hasina, Majumdar Agniva, Chinnaswamy Sreedhar, Srinivasan Narayanaswamy, Dutta Shanta, DAS Saumitra

Abstract excerpt

Direct massively parallel sequencing of SARS-CoV-2 genome was undertaken from nasopharyngeal and oropharyngeal swab samples of infected individuals in Eastern India. Seven of the isolates belonged to the A2a clade, while one belonged to the B4 clade. Specific mutations, characteristic of the A2a clade, were also detected, which included the P323L in RNA-dependent RNA polymerase and D614G in the Spike...

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PMID: 32515358
PMCID: PMC7269891

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