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Article

The myocardial phenotype of Fabry disease pre-hypertrophy and pre-detectable storage.

European heart journal. Cardiovascular Imaging - 22 Jun 2021

Augusto João B, Johner Nicolas, Shah Dipen, Nordin Sabrina, Knott Kristopher D, Rosmini Stefania, Lau Clement, Alfarih Mashael, Hughes Rebecca, Seraphim Andreas, Vijapurapu Ravi, Bhuva Anish, Lin Linda, Ojrzyńska Natalia, Geberhiwot Tarekegn, Captur Gabriella, Ramaswami Uma, Steeds Richard P, Kozor Rebecca, Hughes Derralynn, Moon James C, Namdar Mehdi

Abstract excerpt

AIMS: Cardiac involvement in Fabry disease (FD) occurs prior to left ventricular hypertrophy (LVH) and is characterized by low myocardial native T1 with sphingolipid storage reflected by cardiovascular magnetic resonance (CMR) and electrocardiogram (ECG) changes. We hypothesize that a pre-storage myocardial phenotype might occur even earlier, prior to T1 lowering. METHODS AND RESULTS: FD patients and age-, sex-,...

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Identifiers

PMID: 32514567
DOI: 10.1093/ehjci/jeaa101
PMCID: PMC8219366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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