Malignant teratoid tumor of the thyroid gland: an aggressive primitive multiphenotypic malignancy showing organotypical elements and frequent DICER1 alterations-is the term "thyroblastoma" more appropriate?

doi:10.1007/s00428-020-02853-1

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Article

Malignant teratoid tumor of the thyroid gland: an aggressive primitive multiphenotypic malignancy showing organotypical elements and frequent DICER1 alterations-is the term "thyroblastoma" more appropriate?

Virchows Archiv : an international journal of pathology - 1 Dec 2020

Agaimy Abbas, Witkowski Leora, Stoehr Robert, Cuenca Joseph Christopher Castillo, González-Muller Carlos Alberto, Brütting Alfred, Bährle Markus, Mantsopoulos Konstantinos, Amin Randa M S, Hartmann Arndt, Metzler Markus, Amr Samir S, Foulkes William D, Sobrinho-Simões Manuel, Eloy Catarina

Abstract excerpt

Primary thyroid teratomas are exceedingly rare. Mature and immature variants recapitulate their gonadal counterparts (predilection for infants/children, triphasic germ layer differentiation, and favorable outcome). On the other hand, the so-called malignant teratomas affect predominantly adults and elderly, are highly aggressive, and, according to a few published cases, harbor DICER1 mutations. We describe three...

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PMID: 32507920
DOI: 10.1007/s00428-020-02853-1
PMCID: PMC7683491

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