Exome Sequencing Reveals Common and Rare Variants in F5 Associated With ACE Inhibitor and Angiotensin Receptor Blocker-Induced Angioedema.

doi:10.1002/cpt.1927

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Exome Sequencing Reveals Common and Rare Variants in F5 Associated With ACE Inhibitor and Angiotensin Receptor Blocker-Induced Angioedema.

Clinical pharmacology and therapeutics - 1 Dec 2020

Maroteau Cyrielle, Siddiqui Moneeza Kalhan, Veluchamy Abirami, Carr Fiona, White Myra, Cassidy Andrew J, Baranova Ekaterina V, Rasmussen Eva R, Eriksson Niclas, Bloch Katarzyna M, Brown Nancy J, Bygum Anette, Hallberg Par, Karawajczyk Malgorzata, Magnusson Patrik K E, Yue Qun-Ying, Syvänen Ann-Christine, von Buchwald Christian, Alfirevic Ana, Maitland-van der Zee Anke H, Wadelius Mia, Palmer Colin N A

Abstract excerpt

Angioedema occurring in the head and neck region is a rare and sometimes life-threatening adverse reaction to angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs). Few studies have investigated the association of common variants with this extreme reaction, but none have explored the combined influence of rare variants yet. Adjudicated cases of ACEI-induced angioedema (ACEI-AE)...

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PMID: 32496628
DOI: 10.1002/cpt.1927
PMCID: PMC10306231

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Source receipt: pubmed, retrieved 7 Sept 2026.

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