Article
Phenotypic spectrum and antialbuminuric response to angiotensin converting enzyme inhibitor and angiotensin receptor blocker therapy in pediatric Dent disease.
Molecular genetics & genomic medicine - 1 Aug 2020
Deng Haiyue, Zhang Yanqin, Xiao Huijie, Yao Yong, Zhang Hongwen, Liu Xiaoyu, Su Baige, Guan Na, Zhong Xuhui, Wang Suxia, Ding Jie, Wang Fang
Abstract excerpt
BACKGROUND: To characterize the phenotypic spectrum and assess the antialbuminuric response to angiotensin converting enzyme (ACE) inhibitor and/or angiotensin receptor blocker (ARB) therapy in a cohort of children with Dent disease. METHODS: The patients' clinical findings, renal biopsy results, genetic and follow-up data were analyzed retrospectively. Mutations in CLCN5 or OCRL were detected by next-generation...
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