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Article

Genetic and clinical phenotype of Dent disease in Chinese children and the etiological analysis of early - onset chronic kidney disease.

Italian journal of pediatrics - 8 Dec 2025

Zhou Lanqi, Yu Zuowei, Yang Yuan, Han Yanxinli, Qiu Liru, Zhang Yu, Yang Fengjie, Zhou Jianhua

Abstract excerpt

BACKGROUND: A prominent feature of Dent disease (DD) is the progressive decline in renal function, with 30% - 80% of male patients advancing to end-stage renal disease between the ages of 30 and 50 years. However, limited research exists on the chronic kidney disease (CKD) progression in pediatric patients with DD. This study aimed to retrospectively analyze the clinical features, genetic variant spectrum, and...

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Source

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Identifiers

PMID: 41361832
DOI: 10.1186/s13052-025-02166-6
PMCID: PMC12797435

Genes

CLCN5
OCRL

Provenance

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