Article
Personalized neoantigen vaccination with synthetic long peptides: recent advances and future perspectives.
Theranostics - 1 Jan 2020
Chen Xiaotong, Yang Ju, Wang Lifeng, Liu Baorui
Abstract excerpt
Therapeutic cancer vaccines are one of the most promising strategies of immunotherapy. Traditional vaccines consisting of tumor-associated antigens have met with limited success. Recently, neoantigens derived from nonsynonymous mutations in tumor cells have emerged as alternatives that can improve tumor-specificity and reduce on-target off-tumor toxicity. Synthetic peptides are a common platform for neoantigen...
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