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Article

Granularity of SERPINA1 alleles by DNA sequencing in CanCOLD.

The European respiratory journal - 1 Oct 2020

Gupta Nisha, Gaudreault Nathalie, Thériault Sébastien, Li Pei Zhi, Henry Cyndi, Kirby Miranda, Maltais François, Tan Wan, Bourbeau Jean, Bossé Yohan

Abstract excerpt

DNA sequencing of the SERPINA1 gene to detect α1-antitrypsin (AAT) deficiency (AATD) may provide a better appreciation of the individual and cumulative impact of genetic variants on AAT serum levels and COPD phenotypes.AAT serum level and DNA sequencing of the coding regions of SERPINA1 were performed in 1359 participants of the Canadian Cohort Obstructive Lung Disease (CanCOLD) study. Clinical assessment for...

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Source

Identifiers

PMID: 32482783
DOI: 10.1183/13993003.00958-2020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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