Article
Evidence for Exacerbation-Prone Asthma and Predictive Biomarkers of Exacerbation Frequency.
American journal of respiratory and critical care medicine - 1 Oct 2020
Peters Michael C, Mauger David, Ross Kristie R, Phillips Brenda, Gaston Benjamin, Cardet Juan Carlos, Israel Elliot, Levy Bruce D, Phipatanakul Wanda, Jarjour Nizar N, Castro Mario, Wenzel Sally E, Hastie Annette, Moore Wendy, Bleecker Eugene, Fahy John V, Denlinger Loren C
Abstract excerpt
Rationale: Cross-sectional studies suggest an exacerbation-prone asthma (EPA) phenotype and the utility of blood eosinophils and plasma IL-6 as predictive biomarkers.Objectives: To prospectively test for EPA phenotype and utility of baseline blood measures of eosinophils and IL-6 as predictive biomarkers.Methods: Three-year asthma exacerbation data were analyzed in 406 adults in the Severe Asthma Research...
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