Article
Investigating evidence for a causal association between inflammation and self-harm: A multivariable Mendelian Randomisation study.
Brain, behavior, and immunity - 1 Oct 2020
Russell Abigail Emma, Ford Tamsin, Gunnell David, Heron Jon, Joinson Carol, Moran Paul, Relton Caroline, Suderman Matthew, Hemani Gibran, Mars Becky
Abstract excerpt
BACKGROUND: The causal role of inflammatory markers on self-harm and suicidal risk has been studied using observational data, with conflicting results. Confounding and reverse causation can lead to bias, so we appraised question from a genetic perspective to protect against these biases. We measured associations between genetic liability for high levels of inflammatory markers Interleukin-6 (IL-6) and C-reactive...
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