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Article

The centrosomal/basal body protein OFD1 is required for microtubule organization and cell cycle progression.

Tissue & cell - 1 Jun 2020

Alfieri Mariaevelina, Iaconis Daniela, Tammaro Roberta, Perone Lucia, Calì Gaetano, Nitsch Lucio, Dougherty Gerard W, Ragnini-Wilson Antonella, Franco Brunella

Abstract excerpt

Oral-Facial-Digital type I (OFD1) is a rare inherited form of renal cystic disease associated with ciliary dysfunction. This disorder is due to mutations in the OFD1 gene that encodes a protein localized to centrosomes and basal bodies in different cell types. Immunofluorescence analysis demonstrated that OFD1 displays a dynamic distribution during cell cycle. High-content microscopy analysis of Ofd1-depleted...

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Identifiers

PMID: 32473706
DOI: 10.1016/j.tice.2020.101369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The centrosomal/basal body protein OFD1 is required for microtubule organization and cell cycle progression.PMID 32473706Read ↗

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The centrosomal OFD1 protein interacts with the translation machinery and regulates the synthesis of specific targetsSemantic proximity Read ↗

Mutational spectrum of the oral-facial-digital type I syndrome: a study on a large collection of patients.Semantic proximity Read ↗

The ciliogenic protein Oral-Facial-Digital 1 regulates the neuronal differentiation of embryonic stem cells.Semantic proximity Read ↗

OFD Type I syndrome: lessons learned from a rare ciliopathy.Semantic proximity Read ↗

OFD1: One gene, several disorders.Semantic proximity Read ↗

OFIP/KIAA0753 forms a complex with OFD1 and FOR20 at pericentriolar satellites and centrosomes and is mutated in one individual with oral-facial-digital syndrome.Semantic proximity Read ↗

Novel mutations including deletions of the entire OFD1 gene in 30 families with type 1 orofaciodigital syndrome: a study of the extensive clinical variability.Semantic proximity Read ↗

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