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Studying human reproductive biology through single-cell analysis and in vitro differentiation of stem cells into germ cell-like cells

27 Apr 2020

Abstract excerpt

BACKGROUND: Understanding the molecular and cellular mechanisms of human reproductive development has been limited by the scarcity of human samples and ethical constraints. Recently, in vitro differentiation of human pluripotent stem cells into germ cells and single-cell analyses have opened new avenues to directly study human germ cells and identify unique mechanisms in human reproductive development. OBJECTIVE...

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PMID: 32464645
DOI: 10.1093/humupd/dmaa021

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