Article
Exome-wide association study reveals largely distinct gene sets underlying specific resistance to dengue virus types 1 and 3 in Aedes aegypti.
PLoS genetics - 1 May 2020
Dickson Laura B, Merkling Sarah H, Gautier Mathieu, Ghozlane Amine, Jiolle Davy, Paupy Christophe, Ayala Diego, Moltini-Conclois Isabelle, Fontaine Albin, Lambrechts Louis
Abstract excerpt
Although specific interactions between host and pathogen genotypes have been well documented in invertebrates, the identification of host genes involved in discriminating pathogen genotypes remains a challenge. In the mosquito Aedes aegypti, the main dengue virus (DENV) vector worldwide, statistical associations between host genetic markers and DENV types or strains were previously detected, but the host genes...
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