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Article

A helper-dependent adenoviral vector rescues CFTR to wild-type functional levels in cystic fibrosis epithelial cells harbouring class I mutations.

The European respiratory journal - 1 Nov 2020

Cao Huibi, Ouyang Hong, Laselva Onofrio, Bartlett Claire, Zhou Zhichang Peter, Duan Cathleen, Gunawardena Tarini, Avolio Julie, Bear Christine E, Gonska Tanja, Hu Jim, Moraes Theo J

Abstract excerpt

Cystic fibrosis (CF) is a genetic disorder affecting multiple organs, including the pancreas, hepatobiliary system and reproductive organs; however, lung disease is responsible for the majority of morbidity and mortality. Management of CF involves CF transmembrane conductance regulator (CFTR) modulator agents including corrector drugs to augment cellular trafficking of mutant CFTR as well as potentiators that...

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Identifiers

PMID: 32457197
DOI: 10.1183/13993003.00205-2020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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