Article
CD8+ T-cell senescence and skewed lymphocyte subsets in young Dyskeratosis Congenita patients with PARN and DKC1 mutations.
Journal of clinical laboratory analysis - 1 Sept 2020
Zeng Ting, Lv Ge, Chen Xuemei, Yang Lu, Zhou Lina, Dou Ying, Tang Xuemei, Yang Jun, An Yunfei, Zhao Xiaodong
Abstract excerpt
BACKGROUND: Dyskeratosis congenita (DC) is a syndrome resulting from defective telomere maintenance. Immunodeficiency associated with DC can cause significant morbidity and lead to premature mortality, but the immunological characteristics and molecular hallmark of DC patients, especially young patients, have not been described in detail. METHODS: We summarize the clinical data of two juvenile patients with DC....
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