Article
Novel visualized quantitative epigenetic imprinted gene biomarkers diagnose the malignancy of ten cancer types.
Clinical epigenetics - 24 May 2020
Shen Rulong, Cheng Tong, Xu Chuanliang, Yung Rex C, Bao Jiandong, Li Xing, Yu Hongyu, Lu Shaohua, Xu Huixiong, Wu Hongxun, Zhou Jian, Bu Wenbo, Wang Xiaonan, Si Han, Shi Panying, Zhao Pengcheng, Liu Yun, Deng Yongjie, Zhu Yun, Zeng Shuxiong, Pineda John P, Lin Chunlin, Zhou Ning, Bai Chunxue
Abstract excerpt
BACKGROUND: Epigenetic alterations are involved in most cancers, but its application in cancer diagnosis is still limited. More practical and intuitive methods to detect the aberrant expressions from clinical samples using highly sensitive biomarkers are needed. In this study, we developed a novel approach in identifying, visualizing, and quantifying the biallelic and multiallelic expressions of an imprinted gene...
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