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Article

Impaired mitochondrial function in human placenta with increased maternal adiposity

16 Jul 2014

Abstract excerpt

The placenta plays a key role in regulation of fetal growth and development and in mediating in utero developmental programming. Obesity, which is associated with chronic inflammation and mitochondrial dysfunction in many tissues, exerts a programming effect in pregnancy. We determined the effect of increasing maternal adiposity and of fetal sex on placental ATP generation, mitochondrial biogenesis, expression of...

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Identifiers

PMID: 25028397
DOI: 10.1152/ajpendo.00025.2014

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