TFEB regulates murine liver cell fate during development and regeneration.

doi:10.1038/s41467-020-16300-x

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Article

TFEB regulates murine liver cell fate during development and regeneration.

Nature communications - 18 May 2020

Pastore Nunzia, Huynh Tuong, Herz Niculin J, Calcagni' Alessia, Klisch Tiemo J, Brunetti Lorenzo, Kim Kangho Ho, De Giorgi Marco, Hurley Ayrea, Carissimo Annamaria, Mutarelli Margherita, Aleksieva Niya, D'Orsi Luca, Lagor William R, Moore David D, Settembre Carmine, Finegold Milton J, Forbes Stuart J, Ballabio Andrea

Abstract excerpt

It is well established that pluripotent stem cells in fetal and postnatal liver (LPCs) can differentiate into both hepatocytes and cholangiocytes. However, the signaling pathways implicated in the differentiation of LPCs are still incompletely understood. Transcription Factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy, is known to be involved in osteoblast and myeloid differentiation, but...

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PMID: 32424153
DOI: 10.1038/s41467-020-16300-x
PMCID: PMC7235048

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