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Article

Hypopituitarism in five PROP1 mutation siblings: long-lasting natural course and the effects of growth hormone replacement introduction in middle adulthood.

Pituitary - 1 Aug 2020

Doknic Mirjana, Gasic Vladimir, Stojanovic Marko, Pavlovic Sonja, Marinkovic Snezana, Miljic Dragana, Pekic Sandra, Manojlovic-Gacic Emilija, Damjanovic Dusan, Soldatovic Ivan, Petakov Milan

Abstract excerpt

Twenty years after the first description of combined hypopituitarism (CPHD) caused by PROP1 mutations, the phenotype of affected subjects is still challenging for clinicians. These patients suffer from pituitary hormone deficits ranging from IGHD to panhypopituitarism. ACTH deficiency usually develops later in life. Pituitary size is variable. PROP1 mutation is the most frequent in familial congenital...

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PMID: 32415500
DOI: 10.1007/s11102-020-01049-9

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Hypopituitarism in five PROP1 mutation siblings: long-lasting natural course and the effects of growth hormone replacement introduction in middle adulthood.PMID 32415500Read ↗

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