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High-risk additional chromosomal abnormalities at low blast counts herald death by CML

7 May 2020

Abstract excerpt

Blast crisis is one of the remaining challenges in chronic myeloid leukemia (CML). Whether additional chromosomal abnormalities (ACAs) enable an earlier recognition of imminent blastic proliferation and a timelier change of treatment is unknown. One thousand five hundred and ten imatinib-treated patients with Philadelphia-chromosome-positive (Ph+) CML randomized in CML-study IV were analyzed for ACA/Ph+ and blast...

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PMID: 32382082
DOI: 10.1038/s41375-020-0826-9

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