Article
Co-exposure to multiple metals, TERT-CLPTM1L variants, and their joint influence on leukocyte telomere length.
Environment international - 1 Jul 2020
Bai Yansen, Fu Wenshan, Guan Xin, Wu Xiulong, Li Guyanan, Wei Wei, Feng Yue, Meng Hua, Li Hang, Li Mengying, Fu Ming, Jie Jiali, Wang Chenming, Zhang Xiaomin, He Meian, Guo Huan
Abstract excerpt
OBJECTIVE: Telomere is required for maintaining chromosome stability and genome integrity, while telomere length is sensitive to environmental stressors. We aimed to identify the effects of multiple metals co-exposure as well as their joint effects with TERT-CLPTM1L variants on leukocyte telomere length (LTL). METHODS: This study included 842 workers from a coke-oven plant, of whom plasma concentrations of 23...
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