Article
KATP Channel Mutations and Neonatal Diabetes.
Internal medicine (Tokyo, Japan) - 15 Sept 2017
Shimomura Kenju, Maejima Yuko
Abstract excerpt
Since the discovery of the KATP channel in 1983, numerous studies have revealed its physiological functions. The KATP channel is expressed in various organs, including the pancreas, brain and skeletal muscles. It functions as a "metabolic sensor" that converts the metabolic status to electrical activity. In pancreatic beta-cells, the KATP channel regulates the secretion of insulin by sensing a change in the blood...
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